Octo · H&EBuilt on Kraken

Octo E-N

Eosinophil and neutrophil counts on H&E

Every eosinophil and neutrophil found and counted, with the peak high-power field located for you: eosinophilic gastritis and oesophagitis first, and any biopsy where granulocytes matter.

Granulocytes detected by Kraken on H&EGranulocytes detected by Kraken on H&E
Eosinophils and neutrophils

The peak field, against the threshold

Octo E-N counts eosinophils and neutrophils in every high-power field of the biopsy, so the diagnostic call rests on the highest field on the slide rather than the busiest one someone happened to pick.

Eosinophilic oesophagitisEosinophilic gastritisIBD activityGastritis activity
Threshold
Eosinophils per high-power field, field by fieldIllustrative
The problem

Granulocytes are counted by hand, field by field.

The pathologist scans the biopsy, picks the fields that look busiest and counts eosinophils one by one. Counts near a diagnostic threshold depend on which fields were chosen and who counted them.

Thresholds decide the diagnosis. Eosinophilic oesophagitis and gastritis are diagnosed on counts per high-power field; neutrophils define activity in gastritis and inflammatory bowel disease. A full count, with the peak field shown, makes the threshold call reproducible.

What changes

For the pathologist

Every granulocyte

Eosinophils and neutrophils told apart and counted across the whole biopsy, not in a few chosen fields.

The peak field, found

The highest-density high-power field is located and shown, with its count.

One model, many biopsies

Gastric and oesophageal eosinophils first; the same read applies to colitis activity, gastritis activity and other granulocyte-driven assessments.

Outputs

What you get back

Output
What you get
Format
Eosinophil countper high-power field and per mm², peak and meandata
Neutrophil countper high-power field and per mm², with epithelial involvementdata
Peak-field mapthe densest fields outlined on the slideoverlay
Per-cell exportcoordinates and class for every granulocyteCSV / JSON
Reported to standard

Peak eosinophils per high-power field, reported against published diagnostic thresholds (for example the international consensus on eosinophilic oesophagitis) · Reference →

Evidence

Evidence

38.4
neutrophil detection F1, Kraken (Oct 2026, held-out test)
Whole biopsy
every granulocyte counted, not selected fields
Peak HPF
located and shown
< 2 min
per slide

Product validation for eosinophil counts is in progress. Regulatory status: research use only.

Try Octo E-N

Run it on a slide in the platform, or ask for the product sheet with the full output specification.